Inline purification in continuous flow synthesis – opportunities and challenges

• Jorge García-Lacuna and
• Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

• technique after a synthetic transformation are highlighted in the following section (Scheme 14, Table 3). A continuous flow crystallization was performed using a trisegmented tubular crystallizer (KRAIC) coupled with a catalytic hydration of pyrazine carbonitrile [115]. After passing the reaction setup, the

Is the tungsten(IV) complex (NEt₄)₂[WO(mnt)₂] a functional analogue of acetylene hydratase?

• Matthias Schreyer and
• Lukas Hintermann

Beilstein J. Org. Chem. 2017, 13, 2332–2339, doi:10.3762/bjoc.13.230

• acetylene. A critical assessment of, and a possible explanation for the earlier reported results are offered. The title question is answered with "no". Keywords: acetylene hydratase; alkynes; catalytic hydration; enzyme models; tungsten complexes; Introduction In 1985, the enzyme acetylene hydratase

• test cannot be considered to identify 9 or differentiate it from 10. In short, we find that the analytical evidence presented in ref. [13] to identify 9 was insufficient, and thus the catalytic hydration of 2 to 3 by complex 1 is not proven. In particular, the possibility that acetone was mistaken for

• key vinylidene intermediate. a) Synthesis of complex (NEt4)2[WO(mnt)2] (1) [29]. b) Attempted catalytic hydration reaction with a terminal alkyne. a) Unexpected isolation of acetone 2,4-dinitrophenylhydrazone (10) from an attempted catalytic hydration of ethyne (acetylene gas) in the presence of 1. b

A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring

• John Andraos

Beilstein J. Org. Chem. 2016, 12, 2420–2442, doi:10.3762/bjoc.12.236

• , catalytic hydration of cyclohexene, or catalytic air oxidation of cyclohexane. However, as an intellectual exercise and proof of principle, we may be able to use the results described for integer partitioning to devise creative syntheses for cyclohexanone which involve actual ring construction via 2